Peripheral Vascular Disease Article CONCLUSION: Cilostazol was significantly better than pentoxifylline or placebo for increasing walking distances in patients with intermittent claudication, but was associated with a greater frequency of minor side effects. Cilostazol and Swelling, a phase IV clinical study of FDA ... Headache occurred in 114 (15%) patients in the cilostazol group, whereas 72 (9%) patients had headache in the aspirin group ( P =0.001). Cilostazol is a generally well-tolerated oral medication. Last updated on Nov 2, 2021. Learn more about Cilostazol (Pletal) at EverydayHealth . There is increasing evidence supporting cilostazol's clinical utility. If you notice any other effects, check with your healthcare professional. Renal arteries were not responsive to the effects of cilostazol. It also helps in reducing cramping, numbness, or weakness in the legs that occurs on walking in such patients. blockage of blood flow from left ventricle of the heart. cilostazol side effects. Read the full abstract. These side-effect profiles are similar to those in the literature, and as previously noted by other workers, most side effects settle after 6 weeks.5, 37 In our study, cilostazol was well tolerated, with only four (10.3%) patients discontinuing therapy due to side effects. Cilostazol improves the flow of blood through the blood vessels. . Chest pain. It is used to reduce leg pain caused by poor circulation (intermittent claudication). Authors' conclusions: Cilostazol is more effective than aspirin in the prevention of vascular events secondary to stroke. Baffled to cause for heart attack. Took Pletal 50 mg twice a day. It produces heterogeneous dilation of vascular beds, with greater dilation in femoral beds than in vertebral, carotid or superior mesenteric arteries. to treat peripheral vascular disease. Don't eat or drink grapefruit products while on cilostazol because this can make side effects worse. Cilostazol is a lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group. Three months on Med. Cilostazol is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). Methods We searched PubMed, Scopus and Cochrane databases from 1966 through September 2013 for randomised controlled trials (RCTs) evaluating the addition of . Medicines can help treat PAD. If you have questions, call your doctor. By mouth. Anti-atherosclerotic effect. An overall safety analysis of 2702 patients revealed that the rates of serious cardiovascular events, and all-cause and cardiovascular mortality were similar between drug and placebo groups (27). Side effects of cilostazol may include headache, diarrhea, palpitations, dizziness, and peripheral edema. Cilostazol (Pletal) - Side Effects, 0.1 N HCl, There are no data on whether it results in a reduction of adverse cardiovascular events, It is very important that you take the medicine at about the same time every day, This condition causes reduced blood flow to the legs, Side Effects & Warnings NO ASPIRIN, takes 4weeks for difference, 1-3 months. The most commonly reported side effects included diarrhea, loose stools, flatulence, and nausea. Cardiovascular effects: Cilostazol affects both vascular beds and cardiovascular function. The exact mechanism of this effect is not known, but it has been shown that cilostazol can alter the lipid profile of patients with increases in high-density lipoprotein and lowered triglyceride.8 In addition, it is known to alter monocyte chemoattractant protein-1 which recruits monocytes to . What are the side effects of cilostazol? Cilostazol also improves circulation by keeping platelets in the blood from sticking together and clotting. an abnormally fast . However, the use of PDE3 inhibitors . Cilostazol is also known to have anti-atherosclerotic effects. Decrease blood pressure. Common side effects of cilostazol therapy reportedly include headache (34%), diarrhea (19%), and palpitations (10%). Cilostazol has more minor adverse effects, although there is evidence of fewer bleeds. CLZ has the ability to decrease cellular adenosine uptake and consequently antagonizes side effects of PDE3A inhibition in vital organs. Resting heart rate increases by 5 to 7 beats per minute. Side effects of Cilostazol may include: diarrhea, dizziness, edema (such as swelling of the ankles or legs), headache, stomach pain, or upset stomach. Side effects of cilostazol include: Headache Diarrhea Abnormal stools Infections Runny or stuffy nose Sore throat Dizziness Palpitations Swelling ( edema) of extremities Back pain Indigestion Abdominal pain Fast heart rate Increased cough Muscle pain Atrial fibrillation Left Ventricular Outflow Tract Obstruction [15] A slight elevation in heart rate of 5 to 7 beats/min may also occur with the administration of cilostazol. Background: Cilostazol, a phosphodiesterase III inhibitor, is indicated to treat the symptoms of intermittent claudication and increase walking distance in patients with peripheral arterial disease (PAD). Left ventricular outflow tract obstruction has been reported in patients with sigmoid shaped interventricular septum; monitor for the development of a new systolic murmur or cardiac symptoms after initiating therapy. Cilostazol is a phosphodiesterase III inhibitor with pharmacological effects that include vasodilation, inhibition of platelet activation and aggregation, inhibition of thrombosis, increased blood flow to the limbs, improvement in serum lipids with lowering of triglycerides and elevation of high density lipoprotein cholesterol, and inhibition of vascular smooth muscle cell growth. Cilostazol is a generally well-tolerated oral medication. orthostatic hypotension may occur when taking cilostazol (pletal) which is why you need to what. The phase IV clinical study analyzes which people take Cilostazol and have Swelling. Find everything you need to know about Cilostazol (Pletal), including what it is used for, warnings, reviews, side effects, and interactions. What Are Side Effects Associated with Using Cilostazol? You can use the study as a second opinion to make health care decisions. For Adult. This is a drug that, like other drugs on the market, has a series of adverse . Cilostazol also blocks adenosine uptake, and, subsequently, the interstitial adenosine elevation in the heart could attenuate cAMP response and limit the long-term harmful effects of cAMP activation ( Wang et al., 2001 ). Cilostazol is used to treat the symptoms of intermittent . If you have problems, changing your dose may help. Peripheral vascular disease (PAD) is a chronic progressive atherosclerotic disease leading to partial or total peripheral vascular occlusion. Hiatt WR, Money SR, Brass EP. Although cilostazol was associated with side effects in approximately one-third of patients, most settled within 6 weeks, facilitating the continuation of therapy in >89%. Cilostazol has been associated with spontaneous reports of cardiovascular adverse events and serious bleeding. Some severe side effects are unusual bleeding or bruising, swelling of the arms, hands, feet, ankles, or lower legs and irregular heartbeat. Or, follow the fact sheet that come with them. Methods for treating specific patient groups for sexual dysfunction are provided. Cardiac cath showed arteries around heart good. In summary, cilostazol is a drug that inhibits phosphodiesterase 3, an enzyme that intervenes in different processes of the circulatory system. Cilostazol 50mg Tablet should be taken regularly as advised by the doctor. (C) 2000 by Excerpta Medica, Inc. Cilostazol is used to improve the symptoms of a certain blood flow problem in the legs (intermittent claudication).Cilostazol can decrease the muscle pain/cramps that occur during exercise/walking .